Hubungan Obesitas Menurut Pola Distribusi Lemak Tubuh dengan Kejadian Endometriosis

Authors

  • Amira Masiah Syahvira Fakultas Kedokteran, Universitas Sebelas Maret
  • Eriana Melinawati Fakultas Kedokteran Universitas Sebelas Maret
  • Yusuf Ari Mashuri Fakultas Kedokteran Universitas Sebelas Maret

DOI:

https://doi.org/10.20961/plexus.v1i4.295

Abstract

Latar belakang: Endometriosis merupakan salah satu gangguan ginekologis berkaitan hormon estrogen dan berkembang melalui mekanisme peradangan. Pola distribusi jaringan lemak memiliki kaitan dengan hormon estrogen dan peningkatan masa jaringan lemak dapat mempengaruhi sistem pertahanan tubuh. Penelitian ini bermaksud untuk mempelajari hubungan antara keberadaan jaringan lemak berlebih pada regio tertentu dengan endometriosis.

Metode Penelitian: Studi observasi potong lintang dilakukan pada pasien tindakan pembedahan pada poli obstetri dan ginekologi RSUD Dr. Moewardi dan RS UNS. Sebanyak 87 pasien dibagi menjadi kelompok normal, obesitas sentral, dan obesitas perifer berdasarkan hasil pengukuran indikator antropometri serta dilakukan pendataan konfirmasi endometriosis menurut hasil lab patologi anatomi. Data kemudian dianalisis dengan menggunakan uji kai kuadrat Pearson.

Hasil Peneltian: Subjek pada kelompok endometriosis berusia lebih muda dibandingkan kelompok non endometriosis (p < 0,05). Tidak ada perbedaan berat badan, tinggi badan, dan indeks massa tubuh diantara dua kelompok (p > 0,05). Dismenorrhea dibuktikan berhubungan dengan endometriosis (p > 0,05), namun hubungan tidak ditemukan antara endometriosis dengan infertilitas. Analisis statistik tidak menunjukkan adanya hubungan yang signifikan secara statistik antara obesitas menurut pola distribusi lemak tubuh dengan kejadian endometriosis.

Simpulan Penelitian: Obesitas menurut pola distribusi lemak tubuh tidak berhubungan dengan kejadian endometriosis.

Kata Kunci: endometriosis; adipositas; obesitas; pola distribusi lemak

Keywords:

endometriosis; , adipositas; , obesitas, pola distribusi lemak

References

Amato, M., Pizzolanti, G., Torregrossa, V., Misiano, G., Milano, S., & Giordano, C. (2014). Visceral Adiposity Index (VAI) Is Predictive of an Altered Adipokine Profile in Patients with Type 2 Diabetes. PLoS ONE, 9(3). doi:doi:10.1371/journal.pone.0091969

Backonja, U., Buck Louis, G., & Lauver, D. (2016). Overall Adiposity, Adipose Tissue Distribution, and Endometriosis: A Systematic Review. 65(2), 151-66. doi:10.1097/NNR.0000000000000146

Bourgioti, C., Preza, O., Panourgias, P., Chatoupis, K., Antoniou, A., Nikolaidou, M., & Moulopoulos, L. (2017). MR imaging of endometriosis: Spectrum of disease. Diagnostic and Interventional Imaging, 98(11), 751-767. doi:https://doi.org/10.1016/j.diii.2017.05.009

Bracht, J., Vieira-Potter, V., Santos, R., Öz, O., Palmer, B., & Clegg, D. (2019). The role of estrogens in the adipose tissue milieu. Annals of the New York Academy of Sciences, 1-17. doi:10.1111/nyas.14281

Czernichow, S., Kengne, A. P., Huxley, R. R., Batty, G. D., de Galan, B., Grobbee, D., . . . Group, A. C. (2011). Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 18(2), 312-319. doi:https://doi.org/10.1097/HJR.0b013e32833c1aa3

Czernichow, S., Kengne, A., Huxley, R. R., Batty, G., de Galan, B., Grobbee, D., . . . Chalmers, J. (2011). Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE. 18(2), 312-319.

Delbandi, A., Mahmoudi, M., Shervin, A., Heidari, S., Kolahdouz-Mohammadi, R., & Zarnani, A. (2020). Evaluation of apoptosis and angiogenesis in ectopic and eutopic stromal cells of patients with endometriosis compared to non-endometriotic controls. BMC Women's Health, 20(3). doi:https://doi.org/10.1186/s12905-019-0865-4

Eaton, S., & Sethi, J. (2019). Immunometabolic Links between Estrogen, Adipose Tissue and Female Reproductive Metabolism. Biology, 8(8). doi::10.3390/biology8010008

Giannella, L., Marconi, C., Di Giuseppe, J., Delli Carpini, G., Fichera, M., Grelloni, C., . . . Ciavattini, A. (2021). Malignant Transformation of Postmenopausal Endometriosis: A Systematic Review of the Literature. Cancers (Basel), 13(16). doi:10.3390/cancers13164026

Gregor, M., & Hotamisligil, G. (2011). Inflammatory Mechanisms in Obesity. Annual Review of Immunology, 29(1), 415-445. doi:10.1146/annurev-immunol-031210-101322

Haas, D., Chvatal, R., Reichert, B., Renner, S., Shebl, O., Binder, H., . . . Oppelt, P. (2012). Endometriosis: a premenopausal disease? Age pattern in 42,079 patients with endometriosis. Arch Gynecol Obstet, 2012 Sep;286(3), 667-70. doi:10.1007/s00404-012-2361-z

Hanina, M., Fauzi, A., & Krisna, R. (2018). Hubungan Obesitas Dengan Kejadian Endometriosis di RSUP Dr. Mohammad Hoesin Palembang Periode 1 Januari 2015-31 Desember 2016. Majalah Kedokteran Sriwijaya, 4, 107-113. Dipetik Maret 25, 2020, dari https://ejournal.unsri.ac.id/index.php/mks/article/download/8570/4560

Herrington, J., Bruner-Tan, K., Lucas, J., & Osteen, K. (2011). Immune interactions in endometriosis. Expert Review of Clinical Immunology, 7(8), 611-626. doi:10.1586/eci.11.53

Hetemäki, N., Mikkola, T., Tikkanen, M., Wang, F., Hämäläinen, E., Turpeinen, U., . . . Savolainen-Peltonen, H. (2020). Adipose tissue estrogen production and metabolism in premenopausal women. Journal of Steroid Biochemistry and Molecular Biology, 209(105849). doi:https://doi.org/10.1016/j.jsbmb.2021.105849

Holdsworth-Carson, S., Dior, U., Colgrave, E., Healey, M., Montgomery, G., Rogers, P., & Girling, J. (2018). The association of body mass index with endometriosis and disease severity in women with pain. Journal of Endometriosis and Pelvic Pain Disorder, 10(2), 79-87. doi:10.1177/2284026518773939

Iacobini, C., Pugliese, G., Fantauzzi, C. B., Federici, M., & Menini, S. (2018). Metabolically healthy versus metabolically unhealthy obesity. Metabolism Clinical and Experimental. doi:10.1016/j.metabol.2018.11.009

Kim, M. S., Choi, Y. J., & Lee, Y. H. (2019). Visceral fat measured by computed tomography and the risk of breast cancer. Transl Cancer Res, 8(5), 1939-1949. doi:10.21037/tcr.2019.09.16

Liu, F., He, J., Wang, H., Zhu, D., & Bi, Y. (2020). Adipose Morphology: a Critical Factor in Regulation of Human Metabolic Diseases and Adipose Tissue Dysfunction. OBES SURG, 30, 5086–5100. doi:10.1007/s11695-020-04983-6

Meza-Perez, S., & Randall, T. (2017). Immunological Functions of the Omentum. Immunology, 38(7), 526-536. doi:https://doi.org/10.1016/j.it.2017.03.002

Mori, T., Ito, F., Koshiba, A., Kataoka, H., Takaoka, O., Okimura, H., . . . Kitawaki, J. (2019). Local estrogen formation and its regulation in endometriosis. Reproductive Medicine and Biology, 18(4), 305-311. doi:10.1002/rmb2.12285

Onstad, M., Schmandt, R., & Lu, K. (2016). Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment. Journal of Clinical Oncology, 34(35), 4225-4230. doi:10.1200/JCO.2016.69.4638

Sedlacek, A., Gerber, S., Randall, T., van Rooijen, N., Frelinger, J., & Lor, E. (2013). Generation of a Dual-Functioning Antitumor Immune Response in the Peritoneal Cavity. The American Journal of Pathology, 183(4). doi:http://dx.doi.org/10.1016/j.ajpath.2013.06.030

Shafrir, A., Farland, L., Shah, D., Harris, H., Kvaskoff, M., Zondervan, K., & Missmer, S. (2018). Risk for and consequences of endometriosis: A critical epidemiologic review. Best Practice & Research Clinical Obstetrics and Gynaecology. doi:10.1016/j.bpobgyn.2018.06.001

Tang, Y., Zhao, M., Lin, L., Gao, Y., Chen, G., Chen, S., & Chen, Q. (2020). Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China? BMJ Open, 10(10:e037095). doi:10.1136/bmjopen-2020-037095

Tsatsoulis, A., & Paschou, S. (2020). Metabolically Healthy Obesity: Criteria, Epidemiology, Controversies, and Consequences. Current Obesity Reports, 9(2), 109-120. doi:10.1007/s13679-020-00375-0

Wise, M. R., Jordan, V., Lagas, A., Showell, M., Wong, N., Lensen, S., & Farquhar, C. M. (2016). Obesity and endometrial hyperplasia and cancer in premenopausal women: A systematic review. Am J Obstet Gynecol, 214(6), 689.e1-689.e17. doi:10.1016/j.ajog.2016.01.175

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Published

2022-09-03

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