Faktor Risiko Mortalitas pada Anak dengan COVID-19 di Rumah Sakit Dr. Moewardi Surakarta
DOI:
https://doi.org/10.20961/plexus.v3i3.1032Keywords:
COVID-19, anak, mortalitas, faktor risikoAbstract
Pendahuluan: COVID-19 adalah penyakit infeksi saluran pernapasan yang dapat menyerang semua usia, termasuk anak-anak. Hingga saat ini, penelitian mengenai faktor risiko mortalitas pada pasien anak dengan COVID-19 khususnya di negara berkembang masih terbatas dengan hasil yang bervariasi. Penelitian ini bertujuan untuk menganalisis usia, jenis kelamin, komorbid, status gizi, gejala klinis, temuan laboratorium, dan temuan radiologi sebagai prediktor mortalitas COVID-19.
Metode: Penelitian menggunakan metode deskriptif desain cross sectional, dilakukan pada bulan Maret-September di Rumah Sakit Dr. Moewardi dengan jumlah sampel sebanyak 70 pasien dengan data sekunder dan diolah menggunakan SPSS analisis chi square dan uji regresi logistik.
Hasil: Dari 70 pasien yang diteliti dalam penelitian ini 20% di antaranya mengalami mortalitas. Berdasarkan analisis multivariat terdapa tiga variabel yang memengaruhi mortalitas yaitu komorbid (OR = 82,023, 95% CI: 1,625-4139,152, p = 0,028), status gizi (OR = 43,843, 95% CI: 1,640-1179,148, p = 0,024), dan temuan laboratorium (OR = 70,838, 95% CI 4,222-1188,483, p = 0,003). Sementara variabel usia, jenis kelamin, gejala klinis, dan temuan radiologi tidak menunjukkan hasil yang signifikan pada analisis bivariat.
Kesimpulan: Faktor risiko yang memengaruhi mortalitas yaitu pasien dengan komorbid, status gizi malnutrisi, dan temuan laboratorium abnormal.
References
Abolhassani, H., Delavari, S., Landegren, N., Shokri, S., Bastard, P., Du, L., et al. (2022) ‘Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19’, Journal of Allergy and Clinical Immunology, 150(5), pp. 1059–1073. Available at: https://doi.org/10.1016/j.jaci.2022.09.005
Cai, R., Zhang, J., Zhu, Y., Liu, L., Liu, Y. and He, Q. (2021) ‘Mortality in chronic kidney disease patients with COVID-19: a systematic review and meta-analysis’, International Urology and Nephrology, 53(8), pp. 1623–1629. Available at: https://doi.org/10.1007/s11255-020-02740-3
Choron, R.L., Butts, C.A., Bargoud, C., Krumrei, N.J., Teichman, A.L., Schroeder, M.E., et al. (2021) ‘Fever in the ICU: A Predictor of Mortality in Mechanically Ventilated COVID-19 Patients’, Journal of Intensive Care Medicine, 36(4), pp. 484–493. Available at: https://doi.org/10.1177/0885066620979622
Dewi, R., Kaswandani, N., Karyanti, M.R., Setyanto, D.B., Pudjiadi, A.H., Hendarto, A., et al. (2021) ‘Mortality in children with positive SARS-CoV-2 polymerase chain reaction test: Lessons learned from a tertiary referral hospital in Indonesia’, International Journal of Infectious Diseases, 107(January), pp. 78–85. Available at: https://doi.org/10.1016/j.ijid.2021.04.019
Ejaz, H., Alsrhani, A., Zafar, A., Javed, H. and Junaid, K. (2020) ‘COVID-19 and comorbidities: Deleterious impact on infected patients’, Journal of Infection and Public Health, 13(January), pp. 1833–1839. https://doi.org/10.1016/j.jiph.2020.07.014
Gupta, K., Gandhi, S., Mebane, A. and Singh, A. (2020) ‘Cancer patients and COVID-19 Mortality, serious complications, biomarkers, and ways forward’, (January). https://doi.org/10.1016/j.ctarc.2020.100285
Jin, J.M., Bai, P., He, W., Wu, F., Liu, X.F., Han, D.M., et al. (2020) ‘Gender Differences in Patients With COVID-19: Focus on Severity and Mortality’, Frontiers in Public Health, 8(April), pp. 1–6. Available at: https://doi.org/10.3389/fpubh.2020.00152
Kemenkes RI (2022) Peta Sebaran COVID-19 Indonesia. Available at: https://covid19.go.id/id.
Kim, S.Y., Yoo, D.M., Min, C., Wee, J.H., Kim, J.H. and Choi, H.G. (2020) ‘Analysis of mortality and morbidity in covid-19 patients with obesity using clinical epidemiological data from the korean center for disease control & prevention’, International Journal of Environmental Research and Public Health, 17(24), pp. 1–11. Available at: https://doi.org/10.3390/ijerph17249336
Maddux, A.B. and Douglas, I.S. (2015) ‘Is the developmentally immature immune response in paediatric sepsis a recapitulation of immune tolerance?’, Immunology, 145(1), pp. 1–10. Available at: https://doi.org/10.1111/imm.12454
Moreira, Alvaro, Chorath, K., Rajasekaran, K., Burmeister, F., Ahmed, M. and Moreira, Axel (2021) ‘Demographic predictors of hospitalization and mortality in US children with COVID-19’, European Journal of Pediatrics, 180(5), pp. 1659–1663. Available at: https://doi.org/10.1007/s00431-021-03955-x
Nursofwa, R.F., Sukur, M.H., Kurniadi, B.K. and . H. (2020) ‘Penanganan Pelayanan Kesehatan Di Masa Pandemi Covid-19 Dalam Perspektif Hukum Kesehatan’, Inicio Legis, 1(1), pp. 1–17. Available at: https://doi.org/10.21107/il.v1i1.8822
Poudel, A., Poudel, Y., Adhikari, A., Aryal, B.B., Dangol, D., Bajracharya, T., et al. (2021) ‘D-dimer as a biomarker for assessment of COVID-19 prognosis: D-dimer levels on admission and its role in predicting disease outcome in hospitalized patients with COVID-19’, PLoS ONE, 16(8 August 2021), pp. 1–13. Available at: https://doi.org/10.1371/journal.pone.0256744
Sachdeva, S., Ramakrishnan, S., Choubey, M., Koneti, N., Mani, K., Bakhru, S., et al. (2021) ‘Outcome of COVID-19-positive children with heart disease and grown-ups with congenital heart disease: A multicentric study from India’, Annals of Pediatric Cardiology, 14(3), pp. 269–277. Available at: https://doi.org/10.4103/apc.apc_134_21
Salah, E. and Mokbel, R.A. (2021) ‘Effect of COVID-19 on Children Effect of COVID-19 on Children’, (January). Available at: https://doi.org/10.21608/ejnsr.2020.51687.1029
Satoto, B., Handoyo, T., Sari, M.N.W., Santoso, A.G. and Prasetyo, N.E. (2023) ‘The chest X-ray radiologic severity index as a determinant of the severity of COVID-19 pneumonia: study based on the duration of treatment and inpatient rooms’, Chinese Journal of Academic Radiology, 6(1), pp. 10–17. Available at: https://doi.org/10.1007/s42058-022-00109-2
Seyed Alinaghi, S.A., Karimi, A., Barzegary, A., Mojdeganlou, H., Vahedi, F., Mirghaderi, S.P., et al. (2022) ‘COVID-19 mortality in patients with immunodeficiency and its predictors: a systematic review’, European Journal of Medical Research, 27(1), pp. 1–17. Available at: https://doi.org/10.1186/s40001-022-00824-7
Sharma, A., Farouk, I.A. and Lal, S.K. (2021) ‘COVID-19 : A Review on the Novel Coronavirus Disease’, MDPI Journal Viruses, 13(2), pp. 1–25. Available at: https://doi.org/10.3390/v13020202
Sobhani, S., Aryan, R., Kalantari, E., Soltani, S., Malek, N., Pirzadeh, P., et al. (2021) ‘Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast Iran’, Interdisciplinary Perspectives on Infectious Diseases, 2021(October 2020). Available at: https://doi.org/10.1155/2021/5552138
Song, F., Ma, H., Wang, S., Qin, T., Xu, Q., Yuan, H., et al. (2021) ‘Nutritional screening based on objective indices at admission predicts in-hospital mortality in patients with COVID-19’, Nutrition Journal, 20(1), pp. 1–11. Available at: https://doi.org/10.1186/s12937-021-00702-8
Surendra, H., Elyazar, I.R., Djaafara, B.A., Ekawati, L.L., Saraswati, K., Adrian, V., et al. (2021) ‘Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study’, The Lancet Regional Health - Western Pacific, 9, p. 100108. Available at: https://doi.org/10.1016/j.lanwpc.2021.100108
Swann, O. V., Holden, K.A., Turtle, L., Pollock, L., Fairfield, C.J., Drake, T.M., et al. (2020) ‘Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: Prospective multicentre observational cohort study’, The BMJ, 370. Available at: https://doi.org/10.1136/bmj.m3249.
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., et al. (2020) ‘Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China’, JAMA - Journal of the American Medical Association, 323(11), pp. 1061–1069. Available at: https://doi.org/10.1001/jama.2020.1585.
Yago, M.. R. et al. (2020) ‘Presentation and Outcome of Congenital Heart Disease During Covid-19 Pandemic’, Ann Oncol, (January), pp. 19–21.
Yamada, T., Wakabayashi, M., Yamaji, T. and Chopra, N. (2020) ‘Value of leukocytosis and elevated C-reactive protein in predicting severe coronavirus 2019 (COVID-19) A systematic review and meta-analysis’, (January). https://doi.org/10.1016/j.cca.2020.06.008
Yigit, Y., Haddad, M., Elmoheen, A., Shogaa, M.R., Tawel, R., Mohamed, Y.K., et al. (2021) ‘Can COVID-19 Cause Flare-Ups of Acute Hepatitis B? An Atypical Presentation of COVID-19 with Acute Hepatitis B’, Case Reports in Infectious Diseases, 2021, pp. 1–5. Available at: https://doi.org/10.1155/2021/8818678.
Zhou, F. (2020) ‘Clinical Course And Risk Factors For Mortality Of Adult In Patients With COVID-19 In Wuhan, China: A Retrospective Cohort Study’, Journal of Medicine Study & Research, 3(1), pp. 01–02. Available at: https://doi.org/10.24966/msr-5657/100015.
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