Hubungan Kadar HDL dan LDL dengan Pasien Kanker Payudara yang Telah Menjalani Terapi Hormonal
DOI:
https://doi.org/10.20961/plexus.v4i5.2264Keywords:
HDL, kanker payudara, LDL, terapi hormonalAbstract
Pendahuluan: Pemberian terapi hormonal sebagai anti-estrogen pada pasien kanker payudara diduga dapat mengakibatkan perubahan profil lipid mengingat estrogen memiliki efek protektif yang dapat menurunkan kadar LDL dan meningkatkan kadar HDL. Penelitian ini bertujuan mengetahui karakteristik kadar HDL dan LDL pasien kanker payudara dan menguji apakah terdapat hubungan antara kadar HDL dan LDL dengan pasien kanker payudara yang telah menjalani terapi hormonal minimal 1 tahun.
Metode: Penelitian ini menggunakan desain penelitian observasional analitik menggunakan pendekatan cross sectional. Subjek pada penelitian ini adalah pasien perempuan dan terdiagnosis kanker payudara yang memenuhi kriteria inklusi. Penelitian ini mengukur kadar HDL dan kadar LDL pasien tersebut. Analisis data menggunakan uji bivariat korelasi spearman yang disajikan dalam bentuk tabel distribusi.
Hasil: Hasil penelitian menunjukkan bahwa pada 186 sampel didominasi oleh pasien kanker payudara yang telah menjalani terapi hormonal > 2 tahun (52,15%), kelompok dengan kadar HDL normal (87,63%), kelompok dengan kadar LDL normal (73,66%). Tidak terdapat hubungan antara kadar HDL dengan pasien kanker payudara yang telah menjalani terapi hormonal dengan hasil signifikansi (p= 0,523) dan tidak terdapat hubungan antara kadar LDL dengan pasien kanker payudara yang telah menjalani terapi hormonal dengan hasil signifikansi (p= 0,836).
Kesimpulan: Tidak terdapat hubungan antara kadar HDL dengan pasien kanker payudara yang telah menjalani terapi hormonal dan tidak terdapat hubungan antara kadar LDL dengan pasien kanker payudara yang telah menjalani terapi hormonal.
References
Alomar SA, Găman MA, Prabahar K, Arafah OA, Almarshood F, Baradwan S, Aboudi SAS, Abuzaid M, Almubarki AA, Alomar O, dan Al-Badawi IA (2022). The effect of tamoxifen on the lipid profile in women: A systematic review and meta-analysis of randomized controlled trials. Experimental Gerontology, 159, 111680. https://doi.org/10.1016/j.exger.2021.111680
Berkel C & Cacan E (2024). Half of most frequently mutated genes in breast cancer are expressed differentially between premenopausal and postmenopausal breast cancer patients. Cancer Genetics, 286-287, 11-17. https://doi.org/10.1016/j.cancergen.2024.06.001
Berliana D, Yulistiani Y (2023). An Updated Review of Goserelin as Ovarian Protection in Premenopausal Breast Cancer. Educational Journal of History and Humanities, 6(4), 3038-3047. https://doi.org/10.24815/jr.v6i4.36208
Chen HL, Zhou MQ, Tian W, Meng KX, He HF (2016). Effect of age on breast cancer patient prognoses: a population-based study using the SEER 18 database. PloS one 11(10), e0165409. https://doi.org/10.1371/journal.pone.0165409
Dinas PC, Students of Module 5104 (Introduction to Systematic Reviews), Karaventza M, Liakou C, Georgakouli K, Bogdanos D, Metsios GS (2024). Combined Effects of Physical Activity and Diet on Cancer Patients: A Systematic Review and Meta-Analysis. Nutrients. 16(11), 1749. https://doi.org/10.3390/nu16111749
Fu W, Gao XP, Zhang S, Dai YP, Zou WJ, Yue LM (2020). 17β-Estradiol inhibits PCSK9-mediated LDLR degradation through GPER/PLC activation in HepG2 cells, Frontiers in Endocrinology, 10, 930. https://doi. org/10.3389/fendo
He T, Li X, Li J, Wang Z, Fan Y, Li X, Fu Z, Wu Y, Lv Q, Luo T, Zhong X (2022). Lipid changes during endocrine therapy in breast cancer patients: the results of a 5-year real-world retrospective analysis. Frontiers in Oncology, 11, 670897. https://doi.org/10.3389/fonc.2021.670897
Jia F, Fei S, Tong D, Xue C, Li J (2022). Sex difference in circulating PCSK9 and its clinical implications, Frontiers in Pharmacology, 13, 953845. https://doi.org/10.3389/fphar.2022.953845
Jomard A & Osto E (2020). High density lipoproteins: Metabolism, function, and therapeutic potential, Frontiers in Cardiovascular Medicine; 7, 39. https://doi.org/10.3389/fcvm.2020.00039
Kementerian Kesehataan Republik Indonesia (2021). Bagaimana cara mengukur indeks massa tubuh (IMT) / berat badan normal?. Kemenkes 2021. Diunggah dari: https://p2ptm.kemkes.go.id/infographic-p2ptm/obesitas/bagaimana-cara-mengukur-indeks-massa-tubuh-imt-berat-badan-normal – Diakses Maret 2024
Lavoie JM (2016). Dynamics of hepatic and intestinal cholesterol and bile acid pathways: The impact of the animal model of estrogen deficiency and exercise training, World Journal of Hepatology, 8(23): 961–975. https://doi.org/10.4254/wjh.v8.i23.961
Lemij AA, Bastiaannet E, De Glas NA, van den Bos F, Portielje JE, Liefers GJ dan Derks MG (2023). Breast cancer in the older population: a global challenge-an epidemiological perspective. Annals of Breast Surgery, 7(17), https://doi.org/10.21037/abs-21-89
Li Y, Deng Z, Wang Y, Shen S (2024). Lipid changes during endocrine therapy in early-stage breast cancer patients: A real-world study, Lipids in Health and Disease, 23(1), 9. https://doi.org/10.1186/s12944-024-02002-6
Liu K, Zhang W, Dai Z, Wang M, Tian T, Liu X, Kang H, Guan H, Zhang S, Dai Z (2018). Association between body mass index and breast cancer risk: Evidence based on a dose–response meta-analysis. Cancer management and research, 10, 143-151. https://doi.org/10.2147/CMAR.S144619
Lorga A, Cunningham CM, Moazeni S, Ruffenach G, Umar S, Enghbali M (2017). The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy, Biology of Sex Differences, 8(1), 33. https://doi.org/10.1186/s13293-017-0152-8
Mao X, Omeogu C, Karanth S, Joshi A, Meernik C, Wilson L, Clark A, Deveaux A, He C, Johnson T, Barton K (2023). Association of reproductive risk factors and breast cancer molecular subtypes: a systematic review and meta-analysis. BMC cancer, 23(1), 644. https://doi.org/10.1186/s12885-023-11049-0
Momenimovahed Z & Salehiniya H. (2019). Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer: Targets and Therapy, 11, 151-64. https://doi.org/10.2147/BCTT.S176070
Mooberry LK, Sabnis NA, Panchoo M, Nagarajan B, Lacko AG (2016). Targeting the SR-B1 receptor as a gateway for cancer therapy and imaging. Frontiers in pharmacology, 7, 466. https://doi.org/10.3389/fphar.2016.00466
Natalucci V, Marini CF, Flori M, Pietropaolo F, Lucertini F, Annibalini G, Vallorani L, Sisti D, Saltarelli R, Villarini A, Monaldi S (2021). Effects of a home-based lifestyle intervention program on cardiometabolic health in breast cancer survivors during the COVID-19 lockdown. Journal of Clinical Medicine, 10(12), 2678. https://doi.org/10.3390/jcm10122678
Picon‐Ruiz M, Morata‐Tarifa C, Valle‐Goffin JJ, Friedman ER, Slingerland JM (2017). Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention. CA: a cancer journal for clinicians, 67(5), 378-397. https://doi.org/10.3322/caac.21405
Rillamas-Sun E, Kwan ML, Iribarren C, Cheng R, Neugebauer R, Rana JS et al (2023). Development of cardiometabolic risk factors following endocrine therapy in women with breast cancer, Breast Cancer Research and Treatment 2023, 201(1), 117–126. https://doi.org/10.1007/s10549-023-06997-x
Satherley L & Lloyd Davies E (2023). Breast cancer. Medicine, 51(1), 42–47. https://doi.org/10.1016/j.mpmed.2022.10.008
Sherwood L (2016). Human Physiology : From Cells to System. Edisi 10. Boston: Cengage Learning.
Thayyib, H., Muis, M. ., & Murtala, B. . (2020). Gambaran Ultrasonografi Kelainan Endometrium pada Penderita Kanker Payudara yang Mendapat Terapi Hormonal di Rumah Sakit Wahidin Sudirohusodo. Nusantara Medical Science Journal, 5(2), 87–96. https://doi.org/10.20956/nmsj.v5i2.13408
Yan P, Jimenez ER, Li Z, Bui T, Seehawer M, Nishida J, Foidart P, Stevens LE, Xie Y, Gomez MM, Park SY (2024). Midkine as a driver of age-related changes and increase in mammary tumorigenesis. Cancer Cell, 42(11), 1936-1954. https://doi.org/10.1016/j.ccell.2024.09.002
Yıldırım B, Kulak K, Bilir A (2024). Midkine: A Cancer Biomarker Candidate and Innovative Therapeutic Approaches. European Journal of Breast Health; 20(3): 167-177. https://doi.org/10.4274/ejbh.galenos.2024.2024-4-7
Yoh K, Ikeda K, Horie K, Inoue S (2023). Roles of estrogen, estrogen receptors, and estrogen-related receptors in skeletal muscle: Regulation of mitochondrial function. International Journal of Molecular Sciences, 24(3), 1853. https://doi.org/10.3390/ijms24031853
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