Hubungan Profil Lipid dengan Lama Rawat Inap Pasien Stroke Infark di RSUD Dr. Moewardi
DOI:
https://doi.org/10.20961/plexus.v4i4.2353Keywords:
stroke infark, lama rawat inap, profil lipidAbstract
Pendahuluan: Penyakit stroke merupakan penyebab kematian nomor dua dan salah satu penyebab utama disabilitas di dunia. Penelitian ini bertujuan untuk mengetahui hubungan salah satu komponen faktor risiko stroke, yaitu profil lipid, terhadap lama rawat inap pasien stroke infark.
Metode: Penelitian dilakukan secara observasional analitik menggunakan data rekam medis 385 pasien stroke infark di RSUD dr. Moewardi periode tahun 2022 – 2023.
Hasil: Ditemukan perbedaan yang signifikan antara rata-rata kadar total kolesterol, LDL-C, dan HDL-C pasien yang dirawat < 7 hari dengan ≥ 7 hari. Pasien yang dirawat < 7 hari cenderung memiliki kadar lipid yang lebih tinggi (total kolesterol = 187,12 mg/dL; LDL-C = 125,94 mg/dL; HDL-C = 41,10 mg/dL) dibandingkan pasien yang dirawat ≥ 7 hari (total kolesterol = 176,64 mg/dL; LDL-C = 117,49 mg/dL; HDL-C = 37,97 mg/dL). Pasien yang dirawat < 7 hari juga cenderung tidak memiliki komplikasi serta memiliki skor NIHSS yang lebih rendah.
Kesimpulan: Terdapat hubungan antara kadar total kolesterol, LDL-C, dan HDL-C terhadap lama rawat inap pasien stroke infark. Selain itu, skor NIHSS dan keberadaan komplikasi juga memiliki hubungan terhadap lama rawat inap pasien.
References
Alawneh, K. Z., Qawasmeh, M. Al, Raffee, L. A., & Al-Mistarehi, A. H. (2022). Ischemic stroke demographics, clinical features and scales and their correlations: an exploratory study from Jordan. Future Science OA, 8(7), SIII-S4. https://doi.org/10.2144/fsoa-2022-0017
Ayudia, P., & Imran, Y. (2023). KADAR KOLESTEROL LDL SEBAGAI PREDIKTOR LAMA PERAWATAN PADA PASIEN STROKE ISKEMIK AKUT. JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI, 8(2), 310–320. https://doi.org/10.25105/pdk.v8i2.15710
Babkair, L. A., Safhi, R. A., Balshram, R., Safhei, R., Almahamdy, A., Hakami, F. H., & Alsaleh, A. M. (2023). Nursing Care for Stroke Patients: Current Practice and Future Needs. Nursing Reports, 13(3), 1236–1250. https://doi.org/10.3390/nursrep13030106
Benitez, S., Puig, N., Camps-Renom, P., & Sánchez-Quesada, J. L. (2024). Atherogenic circulating lipoproteins in ischemic stroke. Frontiers in Cardiovascular Medicine, 11(December), 1–11. https://doi.org/10.3389/fcvm.2024.1470364
Bowden, R. G., & Ahmed, T. (2025). Cholesterol Paradox: Understanding and Implications for Clinical Practice and Education. Journal of Clinical Cardiology, 6(1), 18–22. https://doi.org/10.33696/cardiology.6.066
Capuzzi, E., Caldiroli, A., Capellazzi, M., Tagliabue, I., Buoli, M., & Clerici, M. (2020). Biomarkers of suicidal behaviors: A comprehensive critical review (pp. 179–216). https://doi.org/10.1016/bs.acc.2019.11.005
Chen, Q.-J., Lai, H.-M., Chen, B.-D., Li, X.-M., Zhai, H., He, C.-H., Pan, S., Luo, J.-Y., Gao, J., Liu, F., Ma, Y.-T., & Yang, Y.-N. (2016). Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China. International Journal of Environmental Research and Public Health, 13(2), 235. https://doi.org/10.3390/ijerph13020235
Cheng, K. H., Lin, J. R., Anderson, C. S., Lai, W. Ter, & Lee, T. H. (2018). Lipid paradox in statin-naïve acute ischemic stroke but not hemorrhagic stroke. Frontiers in Neurology, 9(AUG). https://doi.org/10.3389/fneur.2018.00541
Daoud, J. I. (2018). Multicollinearity and Regression Analysis. Journal of Physics: Conference Series, 949(1). https://doi.org/10.1088/1742-6596/949/1/012009
Hackam, D. G., & Hegele, R. A. (2019). Cholesterol Lowering and Prevention of Stroke: An Overview. In Stroke (Vol. 50, Issue 2, pp. 537–541). https://doi.org/10.1161/STROKEAHA.118.023167
Hao, R., Qi, X., Xia, X., Wang, L., & Li, X. (2022). Malnutrition on admission increases the in‐hospital mortality and length of stay in elder adults with acute ischemic stroke. Journal of Clinical Laboratory Analysis, 36(1), 1–9. https://doi.org/10.1002/jcla.24132
Hutanu, A., Iancu, M., Dobreanu, M., Oprea, O., Barbu, S., Maier, S., Tero-Vescan, A., Bajko, Z., & Balasa, R. (2021). Extended lipid profile in Romanian ischemic stroke patients in relation to stroke severity and outcome: a path analysis model. Archives of Medical Science, 17(4), 864–873. https://doi.org/10.5114/aoms.2019.89302
Inderhees, J., & Schwaninger, M. (2024). Liver Metabolism in Ischemic Stroke. Neuroscience, 550, 62–68. https://doi.org/10.1016/j.neuroscience.2023.12.013
Ingeman, A., Andersen, G., Hundborg, H. H., Svendsen, M. L., & Johnsen, S. P. (2011). In-hospital medical complications, length of stay, and mortality among stroke unit patients. Stroke, 42(11), 3214–3218. https://doi.org/10.1161/STROKEAHA.110.610881
Jia, C., Anderson, J. L. C., Gruppen, E. G., Lei, Y., Bakker, S. J. L., Dullaart, R. P. F., & Tietge, U. J. F. (2021). High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events. Circulation, 143(20), 1935–1945. https://doi.org/10.1161/CIRCULATIONAHA.120.050808
Langanay, L., Gonzalez Sanchez, R., Hamroun, A., Dauchet, L., Amouyel, P., Dallongeville, J., Meirhaeghe, A., & Gauthier, V. (2024). Ischemic stroke subtypes: risk factors, treatments, and 1-month prognosis – The Lille, France Stroke Registry. Journal of Stroke and Cerebrovascular Diseases, 33(8), 15–19. https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107761
Laulo, A., Tumboimbela, M. J., & Mahama, C. N. (2016). Gambaran profil lipid pada pasien stroke iskemik dan stroke hemoragik yang di rawat inap di Irina F RSUP Prof. Dr. R. D. Kandou Manado periode Juli 2015-Juni 2016. E-CliniC, 4(2). https://doi.org/10.35790/ecl.4.2.2016.14491
Lin, K. H., Lin, H. J., & Yeh, P. S. (2022). Determinants of Prolonged Length of Hospital Stay in Patients with Severe Acute Ischemic Stroke. Journal of Clinical Medicine, 11(12), 0–7. https://doi.org/10.3390/jcm11123457
Liu, J. C., Lei, S. Y., Zhang, D. H., He, Q. Y., Sun, Y. Y., Zhu, H. J., Qu, Y., Zhou, S. Y., Yang, Y., Li, C., & Guo, Z. N. (2024). The pleiotropic effects of statins: a comprehensive exploration of neurovascular unit modulation and blood–brain barrier protection. Molecular Medicine, 30(1). https://doi.org/10.1186/s10020-024-01025-0
Meloun, M., & Militký, J. (2011). 4 - Statistical analysis of multivariate data. In M. Meloun & J. Militký (Eds.), Statistical Data Analysis (pp. 151–403). Woodhead Publishing India. https://doi.org/https://doi.org/10.1533/9780857097200.151
Naing, L., Nordin, R. Bin, Abdul Rahman, H., & Naing, Y. T. (2022). Sample size calculation for prevalence studies using Scalex and ScalaR calculators. BMC Medical Research Methodology, 22(1), 209. https://doi.org/10.1186/s12874-022-01694-7
National Institutes of Health. (2001). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). In NIH Publication (Third). https://doi.org/10.3810/pgm.2000.12.1329
Prakoso, R. A. P., Ardhi, M. S., Thamrin, H., & Setyowatie, S. (2025). Epidemiologic Profile of Ischemic Stroke Patients with Dyslipidemia in Dr. Soetomo General Academic Hospital Patient. AKSONA, 5(1), 12–17. https://doi.org/10.20473/aksona.v5i1.64275
Shafira, R. (2021). Karakteristik Klinis Pasien Stroke Hemoragik di RSUP dr. Mohammad Hosein Palembang pada Tahun 2020 [Sriwijaya University]. https://repository.unsri.ac.id/60164/
Sobesky, J., Madai, V. I., Zweynert, S., Malsch, C., Nabavi, D. G., Audebert, H. J., Kleinschnitz, C., Mackert, B. M., Schmitz, B., Wollenweber, F. A., Haeusler, K. G., Wellwood, I., Wiedmann, S., Endres, M., Dirnagl, U., Meisel, A., & Heuschmann, P. U. (2025). Early Complications After Mild to Moderate Ischemic Stroke and Impact on 3-Month Outcome: The Multicenter Prospective Stroke Unit Plus Cohort Study. Journal of the American Heart Association, 14(4), e032068. https://doi.org/10.1161/JAHA.123.032068
Tim Penyusun SKI 2023. (2023). Survei Kesehatan Indonesia (SKI) 2023 Dalam Angka. https://drive.google.com/file/d/1rjNDG_f8xG6-Y9wmhJUnXhJ-vUFevVJC/view
Tuncar, A., & Cander, B. (2022). Is There a Relationship Between the National Institutes of Health Stroke Scale Scores and Magnetic Resonance Volumetric Measurements in Acute Stroke? The Journal of Tepecik Education and Research Hospital, 32(2), 289–295. https://doi.org/10.4274/terh.galenos.2022.25349
Varela, L. M., Meseguer, E., Lapergue, B., Couret, D., Amarenco, P., & Meilhac, O. (2020). Changes in high-density lipoproteins related to outcomes in patients with acute stroke. Journal of Clinical Medicine, 9(7), 1–15. https://doi.org/10.3390/jcm9072269
Vitturi, B. K., & Gagliardi, R. J. (2022). The prognostic significance of the lipid profile after an ischemic stroke. Neurological Research, 44(2), 139–145. https://doi.org/10.1080/01616412.2021.1967677
WHO. (2021, October 28). World Stroke Day. https://www.who.int/southeastasia/news/detail/28-10-2021-world-stroke-day#:~:text=Globally%2C stroke is the second,tobacco use and alcohol abuse
World Stroke Organization. (2022). Global Stroke Fact Sheet 2022 Purpose : Data sources : World Stroke Organization (WSO), 13, 1–14.
Wuryani, D., & Darumurti, R. C. (2018). Results Characteristics of Lipid Profile Examination of Acute Ischemia Stroke Patients at RSUP Dr. Soedono Madiun, East Java. Sains Medika : Jurnal Kedokteran Dan Kesehatan, 9(1), 3. https://doi.org/10.30659/sainsmed.v9i1.1019
Yaghi, S., & Elkind, M. S. V. (2015). Lipids and Cerebrovascular Disease: Research and Practice. In Stroke (Vol. 46, Issue 11, pp. 3322–3328). https://doi.org/10.1161/STROKEAHA.115.011164
Ye, X., Song, G., Huang, S., Liang, Q., Fang, Y., Lian, L., & Zhu, S. (2022). Caspase-1: A Promising Target for Preserving Blood–Brain Barrier Integrity in Acute Stroke. Frontiers in Molecular Neuroscience, 15(March), 1–16. https://doi.org/10.3389/fnmol.2022.856372
Zhang, A., Deng, W., Zhang, B., Ren, M., Tian, L., Ge, J., Bai, J., Hu, H., & Cui, L. (2021). Association of lipid profiles with severity and outcome of acute ischemic stroke in patients with and without chronic kidney disease. Neurological Sciences, 42(6), 2371–2378. https://doi.org/10.1007/s10072-020-04791-x
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