Hubungan Volume Iodiksanol dengan Perubahan Kadar Serum Kreatinin dan Hematokrit pada Pasien Pasca Angiografi
DOI:
https://doi.org/10.20961/plexus.v4i6.2435Keywords:
Angiografi, Iodiksanol, serum kreatinin, hematokritAbstract
Pendahuluan: Angiografi merupakan teknik memvisualisasikan vaskular dengan media kontras. Serum kreatinin dan hematokrit merupakan salah satu biomarker praktis dalam mendiagnosis gagal ginjal akut dan berpotensi memberikan nilai prognostik pada pasien dengan gagal ginjal akut. Namun, penelitian kejadian gagal ginjal akut pada media media kontras osmolalitas rendah (LOCM) maupun iso-osmolar (IOCM) pada angiografi jalur intraarterial masih menjadi perdebatan dan efek media kontras terhadap kadar hematokrit belum banyak dikemukakan. Penelitian ini bertujuan untuk mengetahui hubungan volume iodiksanol dengan perubahan kadar serum kreatinin dan hematokrit pada pasien pasca angiografi.
Metode: Penelitian observasional analitik desain cohort prospektif pada pasien yang menjalani angiografi di Rumah Sakit Umum Daerah Dr. Moewardi Surakarta pada April 2024 hingga September 2024. Data didapat melalui hasil laboratorium dan rekam medis dan hubungan diantara variabelnya dianalisis dengan uji korelasi Pearson.
Hasil: 31 orang ikut serta dalam penelitian ini. Terdapat signifikansi (p) sebesar 0.034 (p < 0.05) pada hubungan volume iodiksanol dengan perubahan kadar hematokrit pasca angiografi hari ke-2 dengan nilai koefisien korelasi (r) sebesar -0.381. Tidak terdapat signifikansi pada hubungan volume iodiksanol dengan perubahan kadar hematokrit pasca angiografi hari ke-5 (p=0,781; p>0,05), volume iodiksanol dengan perubahan kadar serum kreatinin pasca angiografi hari ke-2 (p=0,968; p>0,05) maupun hari ke-5 (p=0,914; p>0,05), serta hubungan volume iodiksanol dengan perubahan eGFR pasca angiografi hari ke-2 (p=0,820; p>0,05) maupun hari ke-5 (p=0,693; p>0,05).
Kesimpulan: Terdapat hubungan yang signifikan antara volume iodiksanol dengan perubahan kadar hematokrit pada pasien pasca angiografi hari ke-2 di Rumah Sakit Umum Daerah Dr. Moewardi Surakarta.
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