Hubungan Lama Pemberian Antibiotik dengan Infestasi Candida sp. pada Saluran Napas Pasien Pneumonia

Kaisa Zalfa Marselia; Maryani; Desy Puspa  Putri

doi:10.20961/plexus.v5i2.3199

Authors

Kaisa Zalfa Marselia Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, Indonesia
Maryani Departemen Mikrobiologi Klinik, Fakultas Keodokteran, Universitas Sebelas Maret, Surakarta, Indonesia
Desy Puspa Putri Departemen Penyakit Dalam, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, Indonesia

DOI:

https://doi.org/10.20961/plexus.v5i2.3199

Keywords:

Antibiotik, infeksi oportunistik, Candida, Pneumonia

Abstract

Pendahuluan: Pneumonia merupakan masalah kesehatan global dengan angka morbiditas dan mortalitas yang tinggi. Antibiotik sebagai terapi utama pneumonia sering digunakan dalam durasi yang lebih lama dari rekomendasi, yang dapat mengganggu flora normal dan meningkatkan risiko infeksi oportunistik oleh Candida sp. Oleh karena itu, penelitian ini bertujuan menganalisis hubungan antara lama pemberian antibiotik dengan kejadian infeksi Candida sp. pada pasien pneumonia.

Metode: Penelitian ini merupakan studi analitik observasional dengan desain potong lintang retrospektif menggunakan data rekam medis. Sampel diambil dengan teknik total sampling pada pasien pneumonia dengan hasil kultur sputum positif maupun negatif Candida yang memnuhi kriteria inklusi dan eksklusi. Analisis data meliputi analisis univariat, bivariat dan multivariat menggunakan uji Chi-Square, Mann-Whitney, dan uji regresi logistik dengan tingkat signifikansi p<0,05.

Hasil: Hasil analisis data menggunakan uji Mann-whitney didapatkan hubungan yang signifikan antara lama pemberian antibiotik dengan infestasi Candida yang ditandai dengan nilai p = 0,000. Pada uji regresi logistik antara golongan antibiotik dengan hasil kultur Candida sp didapatkan hasil bahwa golongan floroquinolon memiliki hubungan yan bermakna dengan nilai p sebesar 0,001

Kesimpulan: Terdapat hubungan yang signifikan antara lama pemberian antibiotik dengan infestasi Candida sp, serta golongan antibiotik juga turut andil dalam memengaruhi hasil kultur Candida sp. pada saluran napas pasien pneumonia.

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