Perbandingan Kadar Hemoglobin dan Hematokrit pada Early Onset dan Late Onset Preeclampsia di RSUD Dr. Moewardi Surakarta
DOI:
https://doi.org/10.20961/z7k0fw48Keywords:
Preeklampsia, preeklampsia awitan dini, preeklampsia awitan lambat, hemoglobin, hematokritAbstract
Pendahuluan: Preeklampsia merupakan salah satu penyebab tingginya angka kematian ibu, terutama di negara berkembang. Pemeriksaan hematokrit dan hemoglobin adalah salah satu pemeriksaan yang mudah dilakukan di hampir semua fasilitas kesehatan. Banyak penelitian menunjukkan bahwa early onset preeclampsia (EO-PE) dikaitkan dengan kondisi kehamilan yang lebih buruk dibandingkan late onset preeclampsia (LO-PE). Penelitian ini bertujuan untuk mengetahui perbandingan hematokrit dan hemoglobin pada early onset dan late onset preeclampsia sehingga diharapkan dapat menjadi sarana deteksi dini sederhana dan mudah dilakukan, serta berpotensi untuk dikembangkan.
Metode: Penelitian ini merupakan studi cross sectional dengan metode analisis uji T Independen dan regresi logistik. Sampel diambil dari data sekunder berupa rekam medis di RSUD Dr. Moewardi sejak Januari 2021 — Mei 2023.
Hasil: Sampel yang memenuhi kriteria didapatkan 50 wanita dengan EO-PE dan 50 wanita dengan LO-PE. Hasil penelitian ini didapatkan nilai rerata hemoglobin pada EO-PE yaitu 12,852g/dL dan pada LO-PE 11,030 g/dL, dengan perbandingan rerata yang signifikan (p-value 0,000). Sedangkan pada hematokrit didapatkan nilai rerata pada EO-PE yaitu 37,138% dan pada LO-PE didapatkan mean 32,148% dan hasil perbandingan reratanya signifikan (p-value 0,000). Perbandingan hubungan hemoglobin dan hematokrit terhadap onset preeklampsia didapatkan hemoglobin (OR 2,003) lebih berhubungan dengan EO-PE dibandingkan hematokrit (OR 1,219).
Kesimpulan: Mean hemoglobin serta hematokrit pada early onset preeclampsia lebih tinggi secara signifikan dibandingkan dengan late onset preeclampsia. Hemoglobin lebih berhubungan dengan early onset preeclampsia dibandingkan hematokrit.
References
Abildgaard U dan Heimdal K (2013) European Journal of Obstetrics & Gynecology and Reproductive Biology Pathogenesis of the syndrome of hemolysis , elevated liver enzymes , and low platelet count ( HELLP ): a review. European Journal of Obstetrics and Gynecology, 166(2), hal. 117–123. https://doi.org/10.1016/j.ejogrb.2012.09.026
Akhtar S, Any UH dan Fahmi S (2021) Serum Hemoglobin Level in Preeclampsia. 8(1), hal. 39–43.
Anthony J dan Schoeman LK (2013) Fluid management in pre-eclampsia. Obstetric Medicine, 6(3), hal. 100–104. https://doi.org/10.1177/1753495X13486896
Basak SK, Begum K, Rashid M, Yasmin N dan Begum H (2015) Haematocrit Value in Preeclampsia. 30(2), hal. 80–85.
Brown MA, Magee LA, Kenny LC, Karumanchi SA, Mccarthy FP, Saito S, Hall DR, Warren CE, Adoyi G dan Ishaku S (2018) Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice. Hypertension, 72, hal. 24–43. https://doi.org/10.1161/HYPERTENSIONAHA.117.10803
Brunacci F, Rocha VS, Carli E De, Espósito P, Ruano R dan Colli C (2018) Increased serum iron in preeclamptic women is likely due to low hepcidin levels. Nutrition Research. https://doi.org/10.1016/j.nutres.2018.03.005
Daglar K, Kirbas A, Timur H dan Inal ZO (2016) Placental levels of total oxidative and anti- oxidative status, ADAMTS-12 and decorin in early- and late-onset severe preeclampsia. The Journal of Maternal-Fetal & Neonatal Medicine, 7058, hal. 1–6. https://doi.org/10.3109/14767058.2016.1154942
Fallatah AM, Babatin HM, Nassibi KM dan Banweer MK (2019) Maternal and Neonatal Outcomes among Obese Pregnant Women in King Abdulaziz University Hospital : A Retrospective Single-Center Medical Record Review. Med Arch, 73(6), hal. 425–432. https://doi.org/10.5455/medarh.2019.73.425-432
Freitas R De, Vieira A, Medeiros LA, Diniz D dan Id NP (2019) The role of the erythrocyte in the outcome of pregnancy with preeclampsia. PLoS ONE, 14(3), hal. 1–17.
Hayuanta HH (2016) Can Hemoglobin-Hematocrit Relationship Be Used to Assess Hydration Status ? Cermin Dunia Kedokteran, 43(2), hal. 139–142.
Karrar SA dan Hong PL (2023) Preeclampsia. Treasure Island (FL): StatPearls Publishing.
Kemenkes (2021) Profil kesehatan indonesia 2021. Jakarta: Kementerian Kesehatan Republik Indonesia Available at: https://www.kemkes.go.id/id/profil-kesehatan-indonesia-2021.
Kemenkes (2017) Profil Kesehatan Indonesia Tahun 2016. Jakarta: Kementerian Kesehatan RI. 2017 Available at: https://perpustakaan.kemkes.go.id/books/profil-kesehatan-indonesia-tahun-2016/.
Khoigani MG, Goli S dan Hasanzadeh A (2012) The relationship of hemoglobin and hematocrit in the first and second half of pregnancy with pregnancy outcome. Iranian Journal of Nursing and Midwifery Research, 17(2), hal. 165–170.
Kishimoto S, Maruhashi T, Kajikawa M dan Matsui S (2020) Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men. Scientific Reports, 2020(10), hal. 1–9. https://doi.org/10.1038/s41598-020-68319-1
Lahsaee SM, Ghaffaripour S dan Hejr H (2013) The Effect of Routine Maintenance Intravenous Therapy on Hemoglobin Concentration and Hematocrit during Anesthesia in Adults. Bulletin of Emergency and Trauma, 1(3), hal. 102–107.
Li XL, Guo PL, Xue Y, Gou WL, Tong M dan Chen Q (2016) An analysis of the differences between early and late preeclampsia with severe hypertension. Pregnancy Hypertension : An International Journal of Women ’ s Cardiovascular Health, 6(1), hal. 47–52. https://doi.org/10.1016/j.preghy.2015.12.003
Madazli R, Yuksel MA, Tuten A dan Oncul M (2014) Comparison of clinical and perinatal outcomes in early ‑ and late ‑ onset preeclampsia. Archives of Gynecology and Obstetrics, (February), hal. 14–19. https://doi.org/10.1007/s00404-014-3176-x
Mondal H dan Lotfollahzadeh S (2022) Hematocrit. Treasure Island (FL): StatPearls Publishing Available at: https://www.ncbi.nlm.nih.gov/books/NBK542276/
Pakniat H, Movahed F, Bahman A dan Azoor M (2016) The Prediction of Preeclampsia and Its Association With Hemoglobin and Hematocrit in the First Trimester of Pregnancy. Biotech Health Science, 3(3), hal. 3–8. https://doi.org/10.17795/bhs-36810 .Research.
Pinheiro CC, Rayol P, Gozzani L, Machado L, Zampieri G dan Dias CB (2014) The relationship of angiogenic factors to maternal and neonatal manifestations of early-onset and late-onset preeclampsia. Prenatal Diagnosis, 34, hal. 1084–1092. https://doi.org/10.1002/pd.4432
POGI (2016) Pedoman Nasional Pelayanan Kedokteran: Diagnosis dan Tatalaksana Preeklamsia. Perkumpulan Obstetri dan Ginekologi Indonesia Himpunan Kedokteran Feto Maternal Available at: https://pogi.or.id/publish/download/pnpk-dan-ppk/.
Pretorius T, Rensburg G Van, Dyer RA dan Biccard BM (2017) The influence of fluid management on outcomes in pre-eclampsia: A systematic review and meta-analysis. International Journal of Obstetric Anesthesia. https://doi.org/10.1016/j.ijoa.2017.12.004
Quispe-Cornejo AA, Alves AL, Njimi H, Mongkolpun W, Martins ALV, López MA, Creteur J dan Vincent JL (2022) Effects of rapid fluid infusion on hemoglobin concentration : a systematic review and meta ‑ analysis. Critical Care, 26(324), hal. 1–10. https://doi.org/10.1186/s13054-022-04191-x
Staff AC dan Redman CWG (2018) The Differences Between Early- and Late-Onset Pre-eclampsia. In Preeclampsia, Comprehensive Gynecology and Obstetrics. Singapore: Springer Nature, hal. 157–172. https://doi.org/10.1007/978-981-10-5891-2
Stangret A, Skoda M, Wnuk A, Pyzlak M dan Szukiewicz D (2017) Mild anemia during pregnancy upregulates placental vascularity development. Medical Hypotheses, 102, hal. 37–40. https://doi.org/10.1016/j.mehy.2017.03.007
Sumarni (2015) HUBUNGAN ANTARA KADAR HEMOGLOBIN DENGAN KADAR HEMOTOKRIT PADA IBU HAMIL DENGAN PRE EKLAMSIA / EKLAMSIA DI RS MARGONO SOEKARDJO PURWOKERTO eISSN 2477-345X PENDAHULUAN. Midwife Jrunal, 1(2), hal. 7–11.
Wawer AA, Hodyl NA, Fairweather-tait S dan Froessler B (2021) Are Pregnant Women Who Are Living with Overweight or Obesity at Greater Risk of Developing Iron Deficiency / Anaemia ? Nutrients, 13(1572). https://doi.org/10.3390/nu13051572
WHO (2019) Trends in maternal mortality 2000 to 2017: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division. Geneva: World Health Organization Available at: https://www.unfpa.org/sites/default/files/pub-pdf/Maternal_mortality_report.pdf.
Wojtowicz A, Małgorzata MZ-S, Babczyk D, Kołodziejczyk-Pietruszka M, Lewaczy´nska O dan Huras H (2019) Early- and Late-Onset Preeclampsia : A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria. International Journal of Hypertension, 2019. https://doi.org/10.1155/2019/4108271
Zhang P dan Shama N (2022) Early and late onset preeclampsia associated with different placental pathology and clinical risk characteristics. Weill Cornell Medicine. https://doi.org/10.1101/2022.12.05.22282973
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Annisa Rizki Savitri, Wisnu Prabowo, Eric Edwin Yuliantara
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright @2022. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).