Hubungan HbA1c dan Asam Urat dengan Derajat Keparahan Disfungsi Ereksi pada Pasien Diabetes Melitus Tipe 2 di RSUD Dr. Moewardi Surakarta

Gladera Wedpavica Zealtito Zulfan; Eva Niamuzisilawati; Arifin; Dhani Redhono Harioputro

doi:10.20961/plexus.v4i3.1960

Authors

Gladera Wedpavica Zealtito Zulfan Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, Indonesia
Eva Niamuzisilawati Bagian Endokrin, Rumah Sakit Umum Daerah Dr. Moewardi, Surakarta
Arifin Bagian Penyakit Dalam, Rumah Sakit Umum Daerah Dr. Moewardi, Surakarta
Dhani Redhono Harioputro Bagian Penyakit Dalam, Rumah Sakit Umum Daerah Dr. Moewardi, Surakarta

DOI:

https://doi.org/10.20961/plexus.v4i3.1960

Keywords:

disfungsi ereksi, Hemoglobin A1c, asam urat, International Index of Erectile Function, Diabetes melitus tipe 2

Abstract

Pendahuluan: Disfungsi ereksi merupakan salah satu komplikasi tersering pada pasien diabetes melitus tipe 2 yang sering dihubungkan dengan penyakit kardiovaskular. Mendeteksi dini potensi adanya disfungsi ereksi sebagai prediktor penyakit kardiovaskular penting dilakukan. Penelitian ini bertujuan mengetahui hubungan Hemoglobin A1c dan asam urat sebagai indikator dalam memberikan gambaran keparahan disfungsi ereksi.

Metode: Penelitian cross-sectional terhadap pasien laki-laki dengan diabetes melitus tpe 2 di poliklinik endokrin Rumah Sakit Umum Daerah Dr. Moewardi. 32 sampel yang memenuhi kriteria inklusi mengisi kuesioner International Index of Erectile Function (IIEF-5) sebagai klasifikasi derajat disfungsi ereksi. Data diolah menggunakan uji Rank Spearman.

Hasil: Tidak terdapat hubungan yang signifikan antara keparahan disfungsi ereksi dengan Hemoglobin A1c (p>0.05 dan r=0.347) dan asam urat (p>0.05 dan r=0.140) meskipun keduanya memiliki korelasi positif.

Kesimpulan: Tidak terdapat hubungan yang signifikan antara Hemoglobin A1c dan asam urat dengan derajat keparahan disfungsi ereksi.

References

Abdul, S.A., Mallen, C., Hayward, R., Muller, S., Whittle, R., Hotston, M., & Roddy, W. (2017). Gout and subsequent erectile dysfunction: a population-based cohort study from England. Arthritis research & therapy, 19: 1-8.

Adam, D.R., & Alem, M.M. (2022). Erectile dysfunction: Pharmacological pathways with understudied potentials. Biomedicines, 11(1): 46.

Alcaraz, A.A.C., Tharakan, T., Chen, R., Sofikitis, N., & Minhas, S. (2022). The management of erectile dysfunction in men with diabetes mellitus unresponsive to phospodiesterase type 5 inhibitors. Journal Andrology, 11: 257-269.

Anwar, Z., Sinha. V., Mitra, S., Mishra, A.K., Ansari, M.H., Bharti, A., Kumar, V., & Nigam, A. K. (2017). Erectile dysfunction: An underestimated presentation in patients with diabetes mellitus. Indian Journal pf Psychological Medicine, 39(5): 600-603.

Aribas, A., Kayrak, M., Ulucan, S., Keser, A., Demir, K., Alibasic, H., Akili, H., Solak, Y., Avci, A., Turan, Y., Kaya, Z., Katlandur, H., & Kanbay, M. (2014). The relationship between uric acid and erectile dysfunction in hypertensive subjects. Blood Pressure, 23: 370-376.

Asaduzzaman, M., Kamrul, H.A.B., Islam, A., Kabir, M.A., Chanda P.K., Islam, M.A., Sharif, J.M., Ahmed, N., Mandal, T., Ghosh, S., Paul, P. K., Saha, R.K., Hossain, F., Rana, M. S., Alam, K., Kamruzzaman, M., Nandi, A. K., & Siddiqui, N. I. (2020). Frequency and Risk Factors of Erectile Dysfunction among Bangladeshi Adult Men with Type 2 Diabetes Mellitus. Mymensingh medical journal : MMJ, 29(1): 66–72.

Baynest, H.W. (2015). Melitus Klasifikasi, Patofisiologi, Diagnosis dan Penatalaksanaan Diabetes. Jurnal Diabetes dan Metabolisme, 6(5): 1-9.

Birowo, P., Afdal, Atmoko, W., & Brodjonegoro, S.R. (2023). Disfungsi ereksi. Dalam: Atmoko W, Duarsa GWK (eds). Panduan tata laksana disfungsi seksual pria. Edisi ke 1. Jakarta Utara: Ikatan Ahli Urologi Indonesia, pp: 63-91.

Bonasita, P., Ikhsan, M.R., & Pramantara, I.D.P. (2020). Association between HbA1c, blood pressure, lipid profile and erectile function score in patients with type 2 diabetes mellitus at endocrine clinic of Dr. Sardjito general hospital. Repository UGM.

Gao, F., Jiang, B., Cang, Z., Wang, N., Han, B., Li, Q., Chen Y et al., (2017). Serum uric acid is associated with erectile dysfunction: A population based cross-sectional in chinese men. Scientific Reports, 7: 2087.

Giugliano, F., Maiorino, M., & Bellastella, G. (2010). Determinants of erectile dysfunction in type 2 diabetes. Int J Impot Res 22, 204–209.

Karabulut, D., & Yenice, M.G. (2021). Is there any association between uric acid to high-density lipoprotein cholesterol ratio and erectile dysfunction? Grand Journal of Urology, 1(3): 116-121.

Lee, J.W., Lee, S.G., Kim, G.T., Park, E.K., & Kim, H.O. (2015). Determinants of erectile dysfunction in patient with gout. Annals of the Rheumatic Diseases, 74(2).

Mathekga, K.H., Zyl, D.G., & Hanekom, S. (2024). Relationship between glycaemic control and the severity of erectile dysfunction in men with diabetes attending the diabetic clinic at Kalafong Provincial Tertiary Hospital. Journal of Endocrinology, Metabolism and Diabetes of South Africa: 1-6.

McVary, K.T. (2015). Sexual Dysfunction. Dalam: Kasper, D.L., Fauci, A.S., Hauser, S.L., Longo, D.L., Jameson, J.L., & Loscalzo, J (eds). Harrison’s principles of internal medicine. 19 th Edition. New York: McGraw-Hill Education, pp: 324-30.

Myers, A., Haehn, D., Ball, C., Shumate, A., & Broderick, G. (2022). Hemoglobin A1c does not Predict Severity of Erectile Dysfunction.The Journal of Sexual Medicine, 19(4):100-101.

Nisahan, B., Kumanan, T., Rajeshkannan, N., Peranantharajah, T., & Aravinthan, M. (2019). Erectile dysfunction and associated factors among men with diabetes mellitus from a tertiary diabetic center in Northern Sri Lanka. BMC Res Notes 2019, 12(10: 4-9).

Nutalapati, S., Ghagane, S.C., Nerli, R.B., Jali, M.V., & Dixit, N.S. (2020). Association of erectile dysfunction and type 2 diabetes melitus at a tertiary care centre of south India. Diabetes Metabolic Syndrome Clinical Res Rev, 14(4):649-653.

Rahma, N. (2019). Hubungan antara Kadar Hba1c dan Disfungsi Ereksi pada Pasien Diabetes Melitus Tipe 2. Jurnal Mahasiswa PSPD FK Universitas Tanjungpura, 5(2b): 823-832.

Rhoden, E.L., Ribeiro, E.P., Riedner, C.E., Teloken, C., & Souto, C.A.V. (2005). Glycosylated haemoglobin levels and the severity of erectile function in diabetic men. BJUI, 95(4):615-617.

Rochmah, W. (2014). Diabetes melitus pada usia lanjut. Dalam: Setiati, S., Alwi, I., Sudoyo, A.W., Simadibrata, M., Setyohadi, B., & Syam, A.F.. Buku ajar ilmu penyakit dalam jilid I. Edisi ke 6. Jakarta Pusat: Interna Publishing, pp: 2420-4.

Salem, S., Mehrsai, A., Heydari, R., & Pourmand, G. (2014), Serum uric acid as a risk predictor for erectile dysfunction. Journal Sex Medicine. 11(5): 1118-1124.

Sasusabe, N., & Rampengan, S.H. (2016). Disfungsi Ereksi pada Penyakit Kardiovaskular. Jurnal Biomedik (JBM), 8(1): 8-11.

Sherwani, S.I., Khan, H.A., Ekhzaimy, A., Masood, A., & Sakharkar, M.K. (2016). Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients. Biomark Insights, 11: 95-104.

Silitonga, H. (2023). Hubungan Hemoglobin glikosilat (HbA1c), hipertensi dan kebiasaan merokok dengan disfungsi ereksi pria diabetes melitus tipe 2 di RSUP H. Adam Malik dan RS Prof. Dr. Chairuddin Lubis. Universitas Sumatera Utara. Tesis.

Soelistijo, S.A., Suastika, K., Lindarto, D., Decroli, E., Permana, H., Sucipto, K.W., Kusnadi, Y., Budiman, Ikhsan, M. R., Sasiarini, L., Sanusi, H., Nugroho, K. H., Susanto, H. (2021). Pedoman pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia. Jakarta: PB PERKENI, pp: 6-10.

Totaro, M., Dimarakis, S., Castellini, C., D'Andrea, S., Parisi, A., D'Amato, F., Tienforti, D., Palazzi, S., Baroni, M. G., Francavilla, S., & Barbonetti, A. (2022). Erectile dysfunction in hyperuricemia: A prevalence meta‐analysis and meta‐regression study. Andrology, 10(1): 72-81.

Tuokko, A.T., Murtola, T., Korhonen, P., & Kaipia, A. (2021). Hyperuricemia is not an independent predictor of erectile dysfunction. Journal Sexual Medicine, 9:1-9.

Ugwu, T., Ezeani, I., Onung, S., Kolawole, B., & Ikem, R. (2016). Predictors of erectile dysfunction in men with type 2 diabetes mellitus referred to a tertiary healthcare centre. Advances in Endocrinology. http://dx.doi.org/10.1155/2016/9753154

Wang, Y.J., Chen, Y.H., & Fan, L.L. (2024). The association between uric acid and erectile dysfunction in US adults: NHANES 2001-2004. BMC Nephrology, 25(189): 1-7.

Weinberg, A.E., Eisenberg, M., Patel, C.J., Chertow, G.M., & Leppert, J.T. (2014). Diabetes severity, metabolic syndrome, and the risk of erectile dysfunction. Journal Sex Medicine, 10(12): 3102-3109.

Widyaningsih, N., & Ahsani, D.N. (2021), January. Correlation of Age, Duration of Diabetes Mellitus, HbA1c Levels, and Erectile Dysfunctions in Type II Diabetes Mellitus. In 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020). pp. 145-150). Atlantis Press.

Wowor, A.J., Tendean, L.E., & Rumbajan, J.M., (2021). Pengaruh Diabetes Mellitus Terhadap Kejadian Disfungsi Ereksi. eBiomedik, 9(2): 222-228.

Yassin, A.A., Nettleship, J.E., Almehdimadi, Y., Yassin, D.J., El Douaihy, Y., & Saad, F. (2015). Is there a relationship between the severity of erectile dysfunction and the comorbidity profile in men with late onset hypogonadism? Arab J Urol 2015, 13(3):162–8.