Hubungan Kadar Trigliserida dengan Pasien Kanker Payudara yang Telah Mendapatkan Terapi Hormonal
DOI:
https://doi.org/10.20961/plexus.v5i1.2072Keywords:
kanker payudara, terapi hormonal, trigliseridaAbstract
Pendahuluan: Terapi kanker payudara dilakukan dengan menggunakan terapi hormonal. Terapi hormonal diberikan untuk mencegah adanya interaksi estrogen. Ketika estrogen mengalami penurunan, maka akan terjadi peningkatan kadar trigliserida. Peningkatan kadar trigliserida di dalam darah atau yang disebut dengan hipertrigliseridemia dapat meningkatkan berbagai risiko penyakit, salah satunya adalah penyakit kardiovaskular. Penelitian ini bertujuan untuk mengetahui karakteristik kadar Trigliserida pada pasien kanker payudara yang telah mendapatkan terapi hormonal serta mengetahui apakah terdapat hubungan antara penggunaan terapi hormonal dengan kadar serum Trigliserida.
Metode: Penelitian ini menggunakan metode cross sectional dengan jenis penelitian yang digunakan yaitu observasional analitik. Cross sectional dapat diartikan sebagai salah satu penelitian yang dilakukan untuk mengetahui antara faktor risiko (penyebab) dan dampaknya yang dilakukan dalam satu waktu (point time approach).
Hasil: Hasil penelitian menunjukkan bahwa pada 186 sampel didominasi oleh pasien kanker payudara yang telah menjalani terapi hormonal > 2 tahun (52,15%), kelompok dengan kadar HDL normal (87,63%), kelompok dengan kadar LDL normal (73,66%). Tidak terdapat hubungan antara kadar HDL dengan pasien kanker payudara yang telah menjalani terapi hormonal dengan hasil signifikansi (p) = 0,523 dan tidak terdapat hubungan antara kadar LDL dengan pasien kanker payudara yang telah menjalani terapi hormonal dengan hasil signifikansi (p) = 0,865.
Kesimpulan: Hasil akhir adalah tidak didapatkan adanya hubungan antara kadar serum trigliserida dengan penggunaan terapi hormonal pada pasien kanker payudara dengan nilai signifikansi (p)= 0,480.
References
Abduh, M., Alawiyah, T., Apriansyah, G., Sirodj, R.A. and Afgani, M.W (2023). Survey Design: Cross Sectional dalam Penelitian Kualitatif. Jurnal Pendidikan Sains Dan Komputer., 3(01): .31-39. https://doi.org/10.47709/jpsk.v3i01.1955
Admoun, C. and Mayrovitz, H.N (2022). The etiology of breast cancer. Exon Publications. 21-30. https://doi.org/10.36255/exon-publications-breast-cancer-etiology
Alkabban, F.M. dan Ferguson, T (2023). Breast Cancer. [Updated 2022 Sep 26]. StatPearls[https://www.ncbi.nlm.nih.gov/books/NBK482286/]. Treasure Island (FL): StatPearls Publishing.
Alizadeh, M., Ghojazadeh, M., Piri, R., Mirza-Aghazadeh-Attari, M., Mohammadi, S., dan Naghavi-Behzad, M. (2021). Age at diagnosis of breast cancer in Iran: a systematic review and meta-analysis. International Journal of Public Health, 50(8), 6802.mdoi: 10.18502/ijph.v50i8.6802.
Alomar, S.A., Găman, M.-A., Prabahar, K., Arafah, O.A., Almarshood, F., Baradwan, S., Aboudi, S.A.S.A., Abuzaid, M., Almubarki, A.M.A., Alomar, O., Al-Badawi, I.A., Salem, H., dan Abu-Zaid, A. (2022). The effect of tamoxifen on the lipid profile in women: A systematic review and meta-analysis of randomized controlled trials. Experimental Gerontology, 111680. https://doi.org/10.1016/j.exger.2021.111680
Bérczi, B., Farkas, N., Hegyi, P., Tóth, B., Csupor, D., Németh, B., Lukács, A., Czumbel, L.M., Kerémi, B., Kiss, I., Szabó, A., Varga, G., Gerber, G. & Gyöngyi, Z. (2020). Aromatase Inhibitors and Plasma Lipid Changes in Postmenopausal Women with Breast Cancer: A Systematic Review and Meta-Analysis', Journal of Clinical Medicine, 9(6), p. 1821.
Bhardwaj, P., Au, C.C., Benito-Martin, A., Ladumor, H., Oshchepkova, S., Moges, R. and Brown, K.A (2019). Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression. The Journal of steroid biochemistry and molecular biology., 189: 161-170. https://doi.org/10.1016/j.jsbmb.2019.03.002
Cahyanti, D., Rahmayani, A. and Husniar, S.A (2020). Analisis performa metode Knn pada Dataset pasien pengidap Kanker Payudara. Indonesian Journal of Data and Science., 1(2): .39-43. https://doi.org/10.33096/ijodas.v1i2.13
Chang, C.H., Huang, C.W., Huang, C.M., Ou, T.C., Chen, C.C. and Lu, Y.M. (2019). The duration of endocrine therapy and breast cancer patients’ survival: A nationwide population-based cohort study. Medicine, 98(43), p.e17746. https://doi.org/10.1097/MD.0000000000017746
Chu, J., Yang, D., Wang, L. and Xia, J (2020). Nomograms predicting survival for all four subtypes of breast cancer: a SEER-based population study. Annals of translational medicine, 8(8). https://doi.org/10.21037/atm-20-2808
Drãgãnescu, M. and Carmocan, C (2017). Hormone therapy in breast cancer. Chirurgia, 112(4), pp.413-417. https://doi.org/10.21614/chirurgia.112.4.413
Delgado, B.J. and Lopez-Ojeda, W (2019). Estrogen.
Etika, P.N., Isti, S. and Nugraheni, T.L (2019). Hubungan Antara Asupan Energi, Proten, Lemak, Dan Karbohidrat Dengan Kadar Trigliserida Pada Karyawan Poltekkes Kemenkes Yogyakarta (Doctoral dissertation, Poltekkes Kemenkes Yogyakarta).
García-Cortés, D., Hernández-Lemus, E. and Espinal-Enríquez, J (2021). Luminal a breast cancer co-expression network: Structural and functional alterations. Frontiers in genetics, 12, p.629475. https://doi.org/10.3389/fgene.2021.629475
Guo, W., Fu, J., Chen, X., Gao, B., Fu, Z., Fan, H., Cui, Q., Zhu, X., Zhao, Y., Yang, T. and Fan, D (2015). The effects of estrogen on serum level and hepatocyte expression of PCSK9. Metabolism, 64(4), pp.554-560. https://doi.org/10.1016/j.metabol.2015.01.009
Heryani, H., Kusumawaty, J., Gunawan, A. and Samrotul, D (2020). Efektivitas Leaflet terhadap Peningkatan Keterampilan tentang Pemeriksaan Payudara Sendiri (SADARI) pada Remaja Putri di Pondok Pesantren Ar-Risalah Kabupaten Ciamis. Jurnal Ilmu Dan Teknologi Kesehatan, 11(1). https://doi.org/10.33666/jitk.v11i1.237
Irakusuma, S.P (2022). Gambaran Kadar Trigliserida Pada Wanita Menopause Di Wilayah Kerja Puskesmas Banguntapan 1 Bantul (Doctoral dissertation, Poltekkes Kemenkes Yogyakarta). https://doi.org/10.2991/ahsr.k.200723.084
Isobe, H., Shimoda, M., Kan, Y., Tatsumi, F., Katakura, Y., Kimura & Kaneto, H. (2021). A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BMC Endocrine Disorders, 21(1), 115. https://doi.org/10.1186/s12902-021-00780-z
Kobayashi, J., Miyashita, K., Nakajima, K. and Mabuchi, H (2015). Hepatic lipase: a comprehensive view of its role on plasma lipid and lipoprotein metabolism. Journal of atherosclerosis and thrombosis, 22(10), pp.1001-1011. https://doi.org/10.5551/jat.31617
Kusumawaty, J., Gunawan, A., Supriadi, D., Heryani, H., Lismayanti, L. and Milah, D.S (2020), July. Effectiveness of Health Education With Media Leaflet on Knowledge and Attitude of Self-Breast Examination in Young Woman. In the 1st International Conference on Science, Health, Economics, Education and Technology (ICoSHEET 2019) (pp. 334-336). Atlantis Press. https://doi.org/10.2991/ahsr.k.200723.084
Liambo, I. S., Frisitiohady, A., Malaka, M. H., & Kendari, M. (2022). Review: Patofisiologi, Epidemiologi, dan Lini Sel Kanker Payudara. Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan, 8(1), 17-22.
Luo, F., Guo, Y., Ruan, G. Y., Peng, R., & Li, X. P. (2017). Estrogen lowers triglyceride via regulating hepatic APOA5 expression. Lipids in health and disease, 16(1), 72. https://doi.org/10.1186/s12944-017-0463-0
Matsuzawa, Y., Homma, H., Kurachi, H., Nishio, Y., Takeda, T., Yamamoto, T., Adachi, K., Morishige, K.I., Ohmichi, M. and Murata, Y (2017). Estrogen suppresses transcription of lipoprotein lipase gene: existence of a unique estrogen response element on the lipoprotein lipase promoter. Journal of Biological Chemistry, 275(15), pp.11404-11411. https://doi.org/10.1074/jbc.275.15.11404
Nurmayeni, N. and Windarti, I (2022). Gambaran Subtipe Molekuler Kanker Payudara di Indonesia. Jurnal Agromedicine, 9(2), pp.146-149.
Orrantia-Borunda, E., Anchondo-Nuñez, P., Acuña-Aguilar, L. E., Gómez-Valles, F. O., & Ramírez-Valdespino, C. A. (2022). Subtypes of breast cancer. Breast Cancer [https://www.ncbi.nlm.nih.gov/books/NBK583808/]. https://doi.org/10.36255/exon-publications-breast-cancer-subtypes
Peters, A. and Tadi, P (2020). Aromatase inhibitors.
Pratiwi, M. and Damayanty, A.E (2020). Pengaruh Pemberian Susu Kedelai (Glicine Max L. Merr) terhadap Kadar HDL dan LDL pada Wanita Menopause (Studi pada Ibu-Ibu Pengajian Aisyiyah Ranting Melati Medan). Jurnal Ilmiah Kohesi, 4(4), pp.132-137. https://doi.org/10.30596/jih.v1i1.4540
Pirahanchi, Y., Anoruo, M. and Sharma, S., 2022. Biochemistry, lipoprotein lipase. StatPrls [https://www.ncbi.nlm.nih.gov/books/NBK537040/].
Pirahanchi, Y., Sinawe, H. and Dimri, M (2018). Biochemistry, LDL Cholesterol.
Rafida, M., Puspitaningrum, G., Hamida, A., Ramzi, M., Cholishotul, S., Himmah, A.B.F., Dwiputra, F.W., Nugraha, M.T., Sintya, R.F.M. and Noor10, M (2022). Surabaya biomedical journal.
Rahma, A. and Khairun, N.B (2018). Peran Human Epidermal Growth Factor Receptor-2 pada Kanker Payudara. Agromedicine Unila, 5(2), pp.644-647.
Suryan, I., 2020. Pemeriksaan Kadar Trigliserida Pada Masyarakat Peminum Kopi Di RSUD Panyabungan
Sun, Y. S., Zhao, Z., Yang, Z. N., Xu, F., Lu, H. J., Zhu, Z. Y., ... & Zhu, H. P. (2017). Risk factors and preventions of breast cancer. International journal of biological sciences, 13(11), 1387. https://doi.org/10.7150/ijbs.21635
Salim, B. R. K., Wihandani, D. M., & Dewi, N. N. A. (2021). Obesitas sebagai faktor risiko terjadinya peningkatan kadar trigliserida dalam darah: tinjauan pustaka. Intisari Sains Medis, 12(2), 519-523. https://doi.org/10.15562/ism.v12i2.1031
Sibuea, C. V. (2015). Polimorfisme Apolipoprotein A5-1131T> C Tidak Menurunkan Kadar HDL pada Sindroma Metabolik.
Singh, H.K., Prasad, M.S., Kandasamy, A.K. dan Dharanipragada, K. (2016). Tamoxifen‑induced hypertriglyceridemia causing acute pancreatitis. Journal of the Indian Medical Association, 114(3), pp. 58-60. https://doi.org/10.4103/0976-500X.179365
Watuseke, A. E., Polii, H., & Wowor, P. M. (2016). Gambaran kadar lipid trigliserida pada pasien usia produktif di Puskesmas Bahu Kecamatan Malalayang Kota Manado periode November 2014 “Desember 2014. eBiomedik, 4(2). https://doi.org/10.35790/ebm.4.2.2016.13913
Wei, W., Wei, S., Huang, Z., Zhang, Q., Liu, F., Xie, Y., Wei, J., Mo, C., Zhou, Y., Qin, S., Zou, Q., & Yang, J. (2023). The relationship between women’s body mass index and breast cancer outcomes was U-shaped. Frontiers in Oncology, 13, 1191093. https://doi.org/10.3389/fonc.2023.1191093
Xue, J., Yao, Y., Yao, Q., Tian, X., Feng, Y., Su, H., Kong, D., Cui, C., Yan, L., Hao, C. and Zhou, T., (2020). Important roles of estrogen receptor alpha in tumor progression and anti-estrogen therapy of pancreatic ductal adenocarcinoma. Life Sciences, 260, p.118302. https://doi.org/10.1016/j.lfs.2020.118302
Ye, X., Kong, W., Zafar, M.I. and Chen, L.L., (2019). Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies. Cardiovascular diabetology, 18, pp.1-10. https://doi.org/10.1186/s12933-019-0851-z
Yoo, J.J., Lim, Y.S., Kim, M.S., Lee, B., Kim, B.Y., Kim, Z., Lee, J.E., Lee, M.H., Kim, S.G. and Kim, Y.S (2020). Risk of fatty liver after long-term use of tamoxifen in patients with breast cancer. PloS one, 15(7), p.e0236506. https://doi.org/10.1371/journal.pone.0236506
Yu, M., Hazelton, W.D., Luebeck, G.E., Grady, W.M. (2020) . Epigenetic aging: more than just a clock when it comes to cancer. Cancer Research, 80(3), pp. 367–374. https://doi.org/10.1158/0008-5472.CAN-19-0924
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Merrinda Putri, Widyanti Soewoto, Dyonisa Nasirochmi Pakha
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright @2022. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
