Hubungan Glukosa Darah Admisi dan HbA1c dengan Kadar D-Dimer pada Pasien COVID-19 dengan Diabetes Melitus Tipe 2

Ragil Rahma Nafila; Tonang Dwi Ardyanto; Berty Denny Hermawati

doi:10.20961/plexus.v2i3.558

Authors

Ragil Rahma Nafila Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, Indonesia
Tonang Dwi Ardyanto Departemen Patologi Klinik, Rumah Sakit Universitas Sebelas Maret, Surakarta, Indonesia
Berty Denny Hermawati Departemen Penyakit Dalam, Rumah Sakit Universitas Sebelas Maret, Surakarta, Indonesia

DOI:

https://doi.org/10.20961/plexus.v2i3.558

Keywords:

COVID-19, DM tipe 2, glukosa darah admisi, HbA1c; D-Dimer

Abstract

Pendahuluan: Pasien dengan komorbid diabetes melitus (DM) berisiko tinggi mengalami COVID-19 derajat berat bahkan kematian. Hiperglikemia pada pasien DM menyebabkan perubahan aktivitas dan konsentrasi faktor fibrinolitik dan prokoagulan sehingga terjadi peningkatan risiko trombosis. Pemeriksaan yang dapat digunakan sebagai marker hiperkoagulasi yaitu D-Dimer. Penelitian ini bertujuan untuk mengetahui hubungan glukosa darah admisi dan HbA1c dengan kadar D-Dimer pada pasien COVID-19 dengan DM tipe 2 karena belum banyak penelitian mengenai hal ini.

Metode: Desain penelitian yang digunakan yaitu observasional analitik dengan pendekatan cross-sectional. Penelitian menggunakan teknik purposive sampling dari data rekam medis pasien COVID-19 dengan DM tipe 2 di RS UNS pada rentang bulan Agustus 2020 hingga Agustus 2021 yang dirawat inap, dilakukan pemeriksaan kadar D-Dimer admisi, post prandial glucose, dan HbA1c dengan rentang usia ≥ 18 tahun dan < 60 tahun. Data dianalisis dengan Uji Korelasi Sprearman.

Hasil: pasien memenuhi kriteria penelitian. Hasil uji korelasi menunjukkan nilai probabilitas (p) glukosa darah admisi dan HbA1c dengan kadar D-Dimer masing-masing 0,253 dan 0,236 (p > 0,05) dengan koefisien korelasi (r) glukosa darah admisi dan HbA1c secara berurutan 0,098 dan 0,106.

Kesimpulan: Penelitian menunjukkan tidak terdapat hubungan antara glukosa darah admisi dan HbA1c dengan kadar D-Dimer pada pasien Covid-19 dengan DM tipe 2.

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